As Políticas do Governo ea Tendência de Agir de Professores: Explorar as Diferenças das Percepções dos Professores

The aim of the study is to investigate whether there are discrepancies between teachers’ perceptions of the ‘official policies’ and their ‘tendency to act,’ based on their ethical decision-making. A qualitative analysis of 60 Israeli teachers’ questionnaires consisting of critical ethical incidents revealed multifaceted ethical dilemmas nested in categories of ‘discrepancies between official policies and teachers’ tendency to act: ‘Harm (to people, property),’ ‘parental involvement/ interference’ and ‘academic process.’ The discrepancies noted between official policy and teachers’ tendency to act may encourage educational policy to design teachers’ training and professional development programs that include dealing with critical ethical incidents, through team-based simulations and formulating ethical guidelines based on their ethical decision-making process.El objetivo de este estudio es investigar si existen discrepancias entre las percepciones de los docentes sobre “políticas oficiales” y su “tendencia a actuar,” en función de la toma de decisiones éticas. Un análisis cualitativo de 60 cuestionarios tomados a profesores israelíes que presentaban incidentes éticos críticos reveló dilemas éticos multifacéticos anidados en las categorías de “discrepancias entre las políticas oficiales” y “tendencia a actuar” de los docentes: Daño (a personas, propiedades), ‘participación  de docentes/interferencia, y procesos académicos. Las discrepancias observadas entre las políticas oficiales y la tendencia a actuar pueden estimular el diseño de políticas educativas de programas de formación y desarrollo profesional que incluyen incidentes éticos fundamentales, a través de simulaciones en equipo y la formulación de directrices éticas sobre la base de procesos de toma de decisiones éticos.O objetivo deste estudo é investigar se existem discrepâncias entre as percepções dos professores sobre “política oficial” e “tendência para agir”, de acordo com a tomada de decisão ética. A análise qualitativa dos 60 questionários tomadas para professores israelenses que tiveram incidentes críticos éticos revelou dilemas éticos multifacetadas aninhadas nas categorias de “discrepâncias entre as políticas oficiais” e “tendência para agir” de professores: danos (para pessoas, bens), ‘ participação de professores / interferência e processos acadêmicos. As discrepâncias observadas entre as políticas oficiais e para a tendência de agir pode estimular a formulação de políticas educacionais de formação e desenvolvimento profissional, incluindo incidentes éticos fundamentais, através da equipe de simulação eo desenvolvimento de diretrizes éticas com base em processos tomada de decisão ética

Impact of sub-thalamic nucleus deep brain stimulation on dual tasking gait in Parkinson’s disease

Background: The beneficial effects of bilateral sub-thalamic nucleus deep brain stimulation on motor function and gait in advanced Parkinson’s disease are established. Less is known about the effect of stimulation on cognitive function and the capacity to walk while dual tasking, an ability that has been related to fall risk. Everyday walking takes place in complex environments that often require multi-tasking. Hence, dual tasking gait performance reflects everyday ambulation as well as gait automaticity. The purpose of this study was to examine the impact of sub-thalamic nucleus deep brain stimulation on dual task walking in patients with advanced Parkinson’s disease. Methods: Gait was assessed using a performance-based test and by quantifying single-task and dual task walking conditions in 28 patients with advanced Parkinson’s disease. These tests were conducted in 4 conditions: “OFF” medication, with the stimulator turned on and off, and “ON” medication, with the stimulator turned on and off. A previously validated, computerized neuro-psychological battery assessed executive function, attention and memory “OFF” and “ON” deep brain stimulation, after subjects took their anti-Parkinsonian medications. Results: Stimulation improved motor function and the spatiotemporal parameters of gait (e.g., gait speed) during both single-task and dual task walking conditions. Attention improved, but executive function did not. The dual task effect on gait did not change in response to stimulation. For example, during serial 3 subtractions, gait speed was reduced by -0.20 ± 0.14 m/sec while OFF DBS and OFF meds and by -0.22 ± 0.14 m/sec when the DBS was turned on (p = 0.648). Similarly, ON medication, serial 3 subtractions reduced gait speed by -0.20 ± 0.16 m/sec OFF DBS and by -0.22 ± 0.09 m/sec ON DBS (p = 0.543). Conclusions: Bilateral sub-thalamic nucleus deep brain stimulation improves motor symptoms, certain features of gait and even some aspects of cognitive function. However, stimulation apparently fails to reduce the negative impact of a dual task on walking abilities. These findings provide new insight into the effects of deep brain stimulation on gait during cognitively challenging conditions and everyday walking

Factores de riesgo asociados a ITU recurrente en pacientes pediátricos del hospital de Chancay 2020 – 2022

La Infección urinaria (IU) es una las patologías más importantes por su prevalencia e impacto en la población pediátrica, y su recurrencia nos habla de un problema más serio para la salud de nuestro paciente, por lo que evaluar todos los posibles factores que conlleva a esta condición es muy importante. Objetivo: analizar cuáles son aquellos factores que pueden aumentar las probabilidades de presentar una IU recurrente en el Hospital de Chancay. Metodología: hemos realizado una investigación de tipo observacional, analítica de casos y controles, donde los casos fueron aquellos que presentaron IUr, mientras que los controles fueron pacientes que presentaron IU el último año, sin recurrencia. Se analizaron 608 pacientes mediante un modelo de regresión logística binaria, teniendo en cuenta las múltiples variables a estudiar. Resultados: se encontró que el sexo femenino presentaba una OR de 5,861. La uropatología obstructiva no presento una asociación significativa con la IUr. El reflujo VO no pudo ser evaluado de forma retrospectiva, sin embargo, presentó una fuerte asociación con el desarrollo de la IUr. La obesidad nos dio un OR de 2,650. El tratamiento empírico arrojó un OR de 5,815, mientras que la disfunción intestinal no mostro una asociación significativa con la IUr. Conclusiones: ser de sexo femenino, presentar RVO, la obesidad y el tratamiento empírico son considerados factores de riesgo para presentar IUr

Comprehensive Gene and microRNA Expression Profiling Reveals a Role for microRNAs in Human Liver Development

BACKGROUND AND AIMS: microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs post-transcriptionally. miRNAs have been implicated in regulating gene expression in embryonic developmental processes, including proliferation and differentiation. The liver is a multifunctional organ, which undergoes rapid changes during the developmental period and relies on tightly-regulated gene expression. Little is known regarding the complex expression patterns of both mRNAs and miRNAs during the early stages of human liver development, and the role of miRNAs in the regulation of this process has not been studied. The aim of this work was to study the impact of miRNAs on gene expression during early human liver development. METHODS: Global gene and miRNA expression were profiled in adult and in 9-12w human embryonic livers, using high-density microarrays and quantitative RT-PCR. RESULTS: Embryonic liver samples exhibited a gene expression profile that differentiated upon progression in the developmental process, and revealed multiple regulated genes. miRNA expression profiling revealed four major expression patterns that correlated with the known function of regulated miRNAs. Comparison of the expression of the most regulated miRNAs to that of their putative targets using a novel algorithm revealed a significant anti-correlation for several miRNAs, and identified the most active miRNAs in embryonic and in adult liver. Furthermore, our algorithm facilitated the identification of TGFbeta-R1 as a novel target gene of let-7. CONCLUSIONS: Our results uncover multiple regulated miRNAs and genes throughout human liver development, and our algorithm assists in identification of novel miRNA targets with potential roles in liver development

A prospective international multi-center study on safety and efficacy of deep brain stimulation for resistant obsessive-compulsive disorder

Deep brain stimulation (DBS) has been proposed for severe, chronic, treatment-refractory obsessive-compulsive disorder (OCD) patients. Although serious adverse events can occur, only a few studies report on the safety profile of DBS for psychiatric disorders. In a prospective, open-label, interventional multi-center study, we examined the safety and efficacy of electrical stimulation in 30 patients with DBS electrodes bilaterally implanted in the anterior limb of the internal capsule. Safety, efficacy, and functionality assessments were performed at 3, 6, and 12 months post implant. An independent Clinical Events Committee classified and coded all adverse events (AEs) according to EN ISO14155:2011. All patients experienced AEs (195 in total), with the majority of these being mild (52% of all AEs) or moderate (37%). Median time to resolution was 22 days for all AEs and the etiology with the highest AE incidence was 'programming/stimulation' (in 26 patients), followed by 'New illness, injury, condition' (13 patients) and 'pre-existing condition, worsening or exacerbation' (11 patients). Sixteen patients reported a total of 36 serious AEs (eight of them in one single patient), mainly transient anxiety and affective symptoms worsening (20 SAEs). Regarding efficacy measures, Y-BOCS reduction was 42% at 12 months and the responder rate was 60%. Improvements in GAF, CGI, and EuroQol-5D index scores were also observed. In sum, although some severe AEs occurred, most AEs were mild or moderate, transient and related to programming/stimulation and tended to resolve by adjustment of stimulation. In a severely treatment-resistant population, this open-label study supports that the potential benefits outweigh the potential risks of DBS

Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.

Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to be critical in the regulation of gene expression, genomic stability, cell cycle and nuclear architecture. Despite MLL proteins being postulated as essential for normal development, little is known about the specific functions of the different MLL lysine methyltransferases. Here we report heterozygous variants in the gene KMT2B (also known as MLL4) in 27 unrelated individuals with a complex progressive childhood-onset dystonia, often associated with a typical facial appearance and characteristic brain magnetic resonance imaging findings. Over time, the majority of affected individuals developed prominent cervical, cranial and laryngeal dystonia. Marked clinical benefit, including the restoration of independent ambulation in some cases, was observed following deep brain stimulation (DBS). These findings highlight a clinically recognizable and potentially treatable form of genetic dystonia, demonstrating the crucial role of KMT2B in the physiological control of voluntary movement.Funding for the project was provided by the Wellcome Trust for UK10K (WT091310) and DDD Study. The DDD study presents independent research commissioned by the Health Innovation Challenge Fund [grant number HICF-1009-003] - see www.ddduk.org/access.html for full acknowledgement. This work was supported in part by the Intramural Research Program of the National Human Genome Research Institute and the Common Fund, NIH Office of the Director. This work was supported in part by the German Ministry of Research and Education (grant nos. 01GS08160 and 01GS08167; German Mental Retardation Network) as part of the National Genome Research Network to A.R. and D.W. and by the Deutsche Forschungsgemeinschaft (AB393/2-2) to A.R. Brain expression data was provided by the UK Human Brain Expression Consortium (UKBEC), which comprises John A. Hardy, Mina Ryten, Michael Weale, Daniah Trabzuni, Adaikalavan Ramasamy, Colin Smith and Robert Walker, affiliated with UCL Institute of Neurology (J.H., M.R., D.T.), King’s College London (M.R., M.W., A.R.) and the University of Edinburgh (C.S., R.W.)

The influence of contemporary art upon junior high school pupils' creative expression and critical understanding of visual texts in the media

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Franca Pauli and Wolfgang Pauli's bust

Inauguration of Wolfgang Pauli's bus

International conference in the Pauli hall

Conference on agriculture development in new countrie

Franca Pauli at the inauguration of Wolfgang Pauli's bust

Franca Pauli and Felix Bloch in front of Wolfgang Pauli's bus